Aldehyde Oxidase (AO)

Aldehyde Oxidase; AO

Aldehyde Oxidase is a soluble cytoplasmic molybdenum-containing enzyme that is mainly involved in the biotransformation of various drugs and xenobiotics. Aldehyde Oxidase has four isoforms (AOX1, AOX3, AOX3L1, and AOX4). Aldehyde Oxidase is mainly expressed by the liver, but is distributed widely in the lungs, kidneys, brain, and skin. Aldehyde Oxidase catalyzes oxidation and reduction reactions, among which the oxidation of aldehydes, nitro/nitroso compounds or N-heterocycles are more common. Aldehyde Oxidase affects drug metabolism, impacts drug interactions, and generates potential toxic metabolites. Aldehyde Oxidase could lead to liver damage (such as NAFLD), renal toxicity and amyotrophic lateral sclerosis (ALS)^[1]^[2].

References:

[1]. Manevski N, et al., Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery. J Med Chem. 2019 Dec 26;62(24):10955-10994. [Content Brief]

[2]. Pryde DC, et al., Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem. 2010 Dec 23;53(24):8441-60. [Content Brief]

Aldehyde Oxidase (AO) Inhibitor (1)

Aldehyde Oxidase (AO) Related Products (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-13735

Quinacrine	Inhibitor	98.20%
Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC₅₀: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm).

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